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Monticello is a city in and the county seat of Drew County, Arkansas, in the United States. As of the 2010 census it had a population of 9,467.

Founded in 1849 in the Arkansas Timberlands very near the Arkansas Delta region, the city has long been a commercial, cultural and educational hub for southeast Arkansas. With a historically agriculture- and silviculture-based economy, Monticello has diversified to include growth from the medical sector and the University of Arkansas at Monticello.

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